MECHANISM
There are mechanisms for food-drug interactions, however, it can differ due to the medicine you take.
Furthermore, all drug-food interactions are not understood really well, especially new drug interactions require time to discover any particular interactions.
Even then, common medicines which you might have seen at drug stores like panadol and aspirins are mostly discovered and indicated their interactions. And we would like to show particular medicine's mechanisms in this section.
Every drug has different mechanism which will be processed by different enzymes when it is inside the body. Therefore, we will explain different mechanisms that related to type of drugs on our website.
PARACETAMOL
Paracetamol is a p – aminophenol derivative that reveals the activity of analgesic and antipyretic, however, it does not have anti-inflammatory activity.
It is absorbed by the gastrointestinal tract which will be occurred in 10 to 60 minutes after consuming. Then, it is spread into most body tissue and it will be removed in 1 to 3 hours. During the elimination of paracetamol substances, it is metabolized in the liver and excreted in the urine. Furthermore, the liver can be damaged and irreversible if overdose. Metabolized of paracetamol in children is different from adults.
NSAID (NON-STEROIDAL ANTI – INFLAMMATORY DRUG)
Ibuprofen, aspirin, naproxen, indomethacin, nabumetone and others belong to class NSAIDs (nonsteroidal anti-inflammatory drugs). They block the enzyme that produces prostaglandins which are chemicals that were released in the body during inflammation, fever and pain. Thus, the pain, fever and swelling are being reduced.
LORATADINE
Loratadine is piperidine histamine which can block H1 histamine receptor and prevent the allergic reaction that is caused by histamine. It does not have an influence on the brain and nervous system.
MEDICINES FOR GASTROINTESTINAL TRACT
It consists of aluminum, calcium, magnesium or combination which neutralizes the acid of gastrointestinal and prevent the transformation of pepsinogen which the pH rises. Alginic acid reacts with sodium bicarbonate to produce sodium alginate viscous solution which can act as protective barrier.
LOPERAMIDE HYDROCHLORIDE
It decelerates the mobility of intestinal and water and the movement are affected in the bowel. It connects to the receptor in gut which can prevent the production of acetylcholine and prostaglandins. Therefore, it can reduce the volume of fecal. Moreover, the effect of loperamide lasts for 9.1 to 14.4 hours.
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LOZENGES (STREPSILS)
It contains amylmetacresol and dichlorobenzyl alcohol which are mild antiseptic that can eliminate bacteria associating with throat and mouth. Moreover, it can relieve the pain in throat.
INSULIN ASPART
It can regulate glucose metabolism and can attach to insulin receptor that locates on muscle to lower glucose level. In addition, it prevents the production of glucose from the liver.
ROSUVASTATIN
It can increase the uptake of low density cholesterol (LDL) by decreasing hepatic cholesterol. Moreover, it can prevent the synthesis of very low density cholesterol (VLDL). Thus, the LDL and VLDL in the plasma decreases by utilizing rosuvastatin.